Twochem Lab Supply Raw Materials Pharmaceutical Intermediates Powdeapalutamide Powder CAS 956104-40-8 API with 99% Pruity

• Customization: Available
• Formula: C26h21n3o4
• Type: Pharmaceutical Intermediates
• Model NO.: TAPI-30
• Appearance: Powder
• Quality: Pharmaceutical Grade
• Colour: White
• Powder: Yes
• Customized: Customized
• State: Solid
• Purity: >99%
• Certification: GMP, Hse, ISO 9001, USP, Bp
• Suitable for: Poultry, Pets
• Grade Standard: Pharmaceutical Grade
• Shelf Life: 2 Years Proper Storage
• Color: Brick-Red Powder
• Storage: Cool Dry Place
• Model: Tapi-28
• Application: API Raw Materials
• CAS: 956104-40-8
• Test: HPLC
• Assay: 99%
• Sample: Avaliable
• Transport Package: Standard Packaging or Customized to Your Needs
• Specification: 1KG 5KG 25KG 50KG
• Trademark: Twochem
• Origin: Zhejiang Province
• HS Code: 293299909
• Production Capacity: 5000kg/Year

Product Description

 

Our Advantages

1.Free Samples.
2.MOQ:10kg.
3.More than 2000 kinds of animal drugs.
4.More than 11+ manufacturing experience.
5.Certification:MSDS,HALAL,COA,IFRA,ISO9001, ISO22000,26 Allergens, etc.
6.Lead time:about 8-12 working days.
8.Verified by Made-in-China as Golden Supplier.



 

Product Description

 

What is Apalutamide?

Apalutamide is a white powder, Apalutamide is an androgen receptor antagonist with potential antineoplastic activity. Apalutamide binds to AR in target tissues thereby preventing androgen-induced receptor activation and facilitating the formation of inactive complexes that cannot be translocated to the nucleus. Apalutamide prevents binding to and transcription of AR-responsive genes.
Apalutamide ultimately inhibits the expression of genes that regulate prostate cancer cell proliferation and may lead to an inhibition of cell growth in AR-expressing tumor cells.

Product name	Apalutamide
CAS No.	111358-88-4
Molecular Formula	C26H21N3O4
Molecular weight	439.46
Purity	99%
Appearance	White or almost white powder
Package	Aluminum Bag;Drums
Shelf life	2 years

Function of Apalutamide

ARN-509 is a selective and competitive androgen receptor inhibitor with IC50 of 16 nM in a cell-free assay, useful for prostate cancer treatment. Phase 3.
In vitroARN-509 (< 10 μM) inhibits androgen-mediated induction or repression of mRNA expression levels for 13 endogenous genes including PSA and TMPRSS2 in the LNCaP/AR prostate cancer cell line. ARN-509 (< 10 μM) inhibits the proliferative effect of R1881 (30 pM) in the LNCaP/AR prostate cancer cell line. ARN-509 (10 μM) impairs AR nuclear localization and thus reduces the concentration of AR available to bind androgen response elements (ARE) in LNCaP cells expressing AR-EYFP. ARN-509 (10 μM) is able to effectively compete with R1881 (1 nM) and prevent AR from binding to promoter regions. ARN-509 inhibits R1881-induced VP16-AR-mediated transcription with IC50 of 0.2 μM in Hep-G2 cells expressing a VP16-AR fusion protein and an ARE-driven luciferase reporter.

 

Application

 

 

 

 

 

Company Profile

 

 

ShangHai Twochem is one of professional groups specialized in research, development, custom manufacturing and trading of pharmaceutical API, advanced intermediates, food supplements, hookah additive flavors ,Cosmetic raw materials, health and cosmetic raw materials, polypeptides, animal drug and organic reagent  etc. You can select more than 2000 kinds of raw ingredients here. And we are keeping developing new products and continuously marketing them for sale. You will save lots of time , energy, money and have a very pleasant cooperation with us! We have cooperated with local Medicine Inspection Center as our QC center. We have customer manufacture sites managed under GMP guidline in Anhui and Jiangsu Province, China. We have good relationship with many pharmaceutical research Institute and Universities in China. 


 

Factory display

 

 

 

 

 

Q&A
1.How could l get a sample?
Before we received the first order, please afford the sample cost and express fee. We wilreturn  the sample cost back to you within your first order.

2.Can you make designs for us?
We have a professional design team to help our customers do design work.Both OEM and ODM          orders are accepted.

3.Can we get samples from your factory?
We can provide you samples for free, you just pay express cost.

4.Whether you could make our brand on your products?
Yes. We can print your Logo on both the products and the packages if you can meet our MOQ
How can you provide us high quality products?

5.We have a professional QC team, every product is shipped after strictly examination.
What is your lead time?
Quantity about 10000 pcs is 15-20 days ,small orders are about one week.
Huge orders to be neqotiated.

6.What is your payment?
We accept T/T.L/C.Westem union or to be negotiated.Don't worry about anything, if you have      any problems, please feel free to contact us