1.Free Samples.
2.MOQ:10kg.
3.More than 3000 kinds of animal drugs.
4.More than 11+ manufacturing experience.
5.Certification:MSDS,HALAL,COA,IFRA,ISO9001, ISO22000,26 Allergens, etc.
6.Lead time:about 8-12 working days.
8.Verified by Made-in-China as Golden Supplier.
What is Conopeptide/Xep-018 Powder
The cone snail is a venomous tropical marine mollusk and is said to be one of the 500 most venomous creatures in the world. Cono snails can produce polypeptide venom for predation and defense. Each conch venom of the conch family may contain up to 200 pharmacologically active ingredients. The cono peptides used in cosmetics are biologically simulated cono toxins that have been genetically sequenced and artificially Biomimetic synthesis preserves biological activity and efficacy while reducing most of the toxicity. The arginine/glutamine component in the ingredient list is conopeptide.
Cone snails, also known as cone snails, belong to the cone snail superfamily of the marine gastropod family Cone superfamily. This family also includes poisonous molluscs such as Talisidae and Asparagus family. There are more than 500 species of cones in the world.
Conus snails can secrete a special type of polypeptide venom through the venom tube, which is used for prey and defense. This polypeptide venom is a very biologically active peptide, composed of many small peptides, and has strong penetrating power. , high stability, and can achieve the ultimate relaxation and stretching effect on muscles. Reduce damage to fibroblasts and collagen, avoid excessive cross-linking of skin collagen, and protect the skin.
Conotide is known as "smear-based toxin" and "anti-wrinkle artifact". It has strong neurotoxicity. In the fields of neuroscience, drug development and other fields, conotide has been studied and applied in many fields. In the field of cosmetics, cosmetics based on conopeptides have also been developed to remove facial wrinkles due to their ability to inhibit muscle contraction.
Xep-18 is a highly folded peptide with strong penetration, high stability, and targeted muscle relaxation. By blocking the current conduction of nerves and muscles, wrinkles are instantly diminished, and the skin rejuvenates and looks younger.
Function of Conopeptide/Xep-018 Powder
• It helps to increase the synthesis of glycosaminoglycans (GAGs) and proteoglycans (PGs) in the dermis, which are important components of the extracellular matrix (ECM) that provide hydration, elasticity, and firmness to the skin.
• It helps to strengthen the connection between the epidermis and the dermis, which are the two main layers of the skin. This connection, known as the dermal-epidermal junction (DEJ), is vital for the skin's health, regeneration, and communication. When the DEJ is damaged, the skin can show signs of aging, such as wrinkles, sagging, thinning, and sensitivity.
• It helps to interact with growth factors and cytokines, which are molecules that regulate the skin's balance and aging process.
Developed by a Swiss laboratory with a background in biotechnology and pharmaceutical research, it mimics a neurotoxin, Conotoxin Biological Action: A neural component that causes muscles to relax without paralyzing muscle activity. Its efficacy is similar to that of Botox. Helps relieve wrinkles in a shorter period of time.
Conotide is a highly folded peptide with strong penetration, high stability, and targeted muscle relaxation. Conotide specifically blocks voltage-dependent sodium ion channels, specifically those in muscles. Conotoxin actually simulates the peptide component of conotoxin, so it is also called "conotoxin peptide" in some places. As reflected in the ingredient list, it is actually called "arginine/lysine peptide".
The ingredient list of cosmetics shows arginine/lysine, the most popular anti-aging ingredients at the moment. The effect is very significant. It is called smear-type toxin. One application can last for 8 hours, and it will fade after long-term application. Fine lines and delay skin aging. There are not many representative products on the market, and they are now popular in beauty salons.
Conotoxin has a relatively small molecular weight and extremely high target selectivity for voltage-gated channels. As a gated regulator of sodium ion channels, it can block voltage-dependent sodium channels for a long time, thereby regulating skeletal muscle expression, thereby achieving muscle Relaxing effect and quick and immediate anti-wrinkle effect.
From a mechanism point of view, conopeptide can inhibit the signal transmission of muscle contraction at multiple targets, retaining only 5% of neuromuscular current conduction, effectively relaxing the muscles without "paralyzing" the muscles, so it can provide a very natural and instantaneous Effect. Let's go directly to the verification of clinical data! After the subjects used 3% concentration of conopeptide, fine lines under the eyes were significantly reduced. The effect is already very significant in a short period of time (15 minutes), with an effective rate of up to 90%, and the effect lasts for 12 hours.
| tems |
Specifications |
| MOQ |
10 vials |
| Delivery |
Sent out within 12 hours after payment confirmed |
| CAS |
1936616-33-0 |
| Appearance |
Lyophilized powder |
| Molecular Formula |
C18291N55O51S2 |
| Molecular Weight |
4174.77000 |
| Purtity |
99% |
| Packing |
As your request |
| Storage |
Preserve in tight, light-resistant containers in a cool place |
| Custom synthesis |
Available |
| payment |
Bank Transfer, Western Union, Money Gram and Bitcoin |
| Storage condition |
-20°C |
| COA/HPLC |
Available |
ShangHai Twochem is one of professional groups specialized in research, development, custom manufacturing and trading of pharmaceutical API, advanced intermediates, food supplements, hookah additive flavors ,Cosmetic raw materials, health and cosmetic raw materials, polypeptides, animal drug and organic reagent etc. You can select more than 2000 kinds of raw ingredients here. And we are keeping developing new products and continuously marketing them for sale. You will save lots of time , energy, money and have a very pleasant cooperation with us! We have cooperated with local Medicine Inspection Center as our QC center. We have customer manufacture sites managed under GMP guidline in Anhui and Jiangsu Province, China. We have good relationship with many pharmaceutical research Institute and Universities in China.
Q&A
1.How could l get a sample?
Before we received the first order, please afford the sample cost and express fee. We wilreturn the sample cost back to you within your first order.
2.Can you make designs for us?
We have a professional design team to help our customers do design work.Both OEM and ODM orders are accepted.
3.Can we get samples from your factory?
We can provide you samples for free, you just pay express cost.
4.Whether you could make our brand on your products?
Yes. We can print your Logo on both the products and the packages if you can meet our MOQ
How can you provide us high quality products?
5.We have a professional QC team, every product is shipped after strictly examination.
What is your lead time?
Quantity about 10000 pcs is 15-20 days ,small orders are about one week.
Huge orders to be neqotiated.
6.What is your payment?
We accept T/T.L/C.Westem union or to be negotiated.Don't worry about anything, if you have any problems, please feel free to contact us
Audited Supplier 
){kind=link}