| Customization: | Available |
|---|---|
| CAS No.: | 115144-35-9 |
| Formula: | C11h9kN2o3s2 |
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English name D-Luciferinpotassiumsalt
CAS number 115144-35-9
Molecular formula C11H9KN2O3S2
Molecular weight 320.42
D-Luciferin is the substrate of firefly luciferase, and its quantum efficiency is 0.88, which is 20 times that of Luminol. D-Luciferin is a commonly used substrate for luciferase and is widely used in the entire field of biotechnology, especially in vivo imaging technology. Its mechanism of action is that under the action of ATP and luciferase, luciferin (substrate) can be oxidized and emit light. When there is an excess of luciferin, the number of light quanta produced is positively correlated with the concentration of luciferase. After the plasmid carrying the luciferase encoding gene (Luc) is transfected into cells, it is introduced into research animals such as rats and mice, and then luciferin is injected to detect changes in light intensity through bioluminescence imaging technology to monitor the development of the disease in real time. Or the therapeutic effect of drugs, etc. The influence of ATP on this reaction system can also be used to indicate energy or vital signs based on changes in bioluminescence intensity.
Function of D-Luciferin potassium salt CAS 115144-35-9
D-Luciferin potassium salt(115144-35-9) is a water soluble form of D-Luciferin. D-Luciferin is a common bioluminescent substrate used for imaging of firefly luciferase expression with peak chemiluminescent emission at 560 nm. The ATP dependant luciferin oxidation is catalyzed by the Luciferase enzyme encoded by lucgene.
D-Luciferin Potassium Salt is a class of light-emitting heterocyclic compounds found in organisms that cause bioluminescence, such as firefly. This compound creates light through the process of oxidative decarboxylation by luciferase while ATP is present. In cell culture, D-Luciferin Potassium Salt is used to achieve highly sensitive bioluminescence detection. Recently, Luciferin was used to measure the uptake of mRNA in preparation of the vaccine against .
D-Luciferin may be used as a substrate in luciferase-based (EC 1.13.12.7) bioluminescence imaging and cell-based high-throughput screening applications. ATP can be measured with a reagent made up of D-luciferin and luciferase from firefly. D-Luciferin may be used and studied as a partial agonist for G protein-coupled receptor-35 (GPR35). Used for imaging the expression of the LUC marker gene and luciferase-fusion conjugates in living cells, tissues and organisms. Extensively utilized in reporter gene assays, immunoassays and hygiene monitoring.
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