Customization: | Available |
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CAS No.: | 55028-72-3 |
Formula: | C22h30clnao6 |
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Product Name: | (±)-Cloprostenol sodium salt |
Synonyms: | 15-EPI CLOPROSTENOL;15(S)-CLOPROSTENOL;16-(3-CHLOROPHENOXY)-9,11,15R-TRIHYDROXY-17,18,19,20-TETRANORPROSTA-5Z,13E-DIEN-1-OIC ACID SODIUM SALT;(+)-16-M-CHLOROPHENOXY TETRANOR PROSTAGLANDIN F2ALPHA SODIUM SALT;7-(2-[4-(3-Chlorophenoxy)-3-hydroxy-1-butenyl]-3,5-dihydroxycyclopentyl)-5-heptenoic acid;(5Z)-rel-Cloprostenol SodiuM;DL-Cloprostenol sodiuM;(+/-)-16-(3-Chlorophenoxy)-9,11,15R-trihydroxy-17,18,19,20-tetranorprosta-5Z,13E-dien-1-oic acid hydrate sodium salt |
CAS: | 55028-72-3 |
MF: | C22H30ClNaO6 |
MW: | 448.92 |
EINECS: | 259-439-3 |
Product Categories: | Other APIs;Pharmaceuticals;Pharmaceutical Raw Materials;Prostaglandins;Chiral Reagents;Intermediates & Fine Chemicals |
Mol File: | 55028-72-3.mol |
Description | ±)-Cloprostenol sodium salt is the d-enantiomer of Cloprostenol (C587300), an aryl-oxymethyl analog of prostaglandin F2α. |
Uses | (±)-Cloprostenol sodium salt is a prostaglandin that dissolves the corpus luteum of cattle and is used as a veterinary drug. |
Brand name | Estrumate(Bayer Animal Health). |
General Description | Cloprostenol sodium (Estrumate)is available as the sodium salt from Bayer AgriculturalDivision or Bayvet Division of Miles Laboratory as an aqueoussolution containing 250 mg/mL. |
Biological Activity | Water-soluble prostaglandin F 2 α (PGF 2 α ) analog; acts as a potent FP receptor agonist (EC 50 = 0.84 nM). Potently inhibits differentiation of adipocyte precursor cells. Luteolytic agent in vivo . |
Side effects | A low incidence of clostridial and other infections at the injection site has been reported following prostaglandin administration. Treated animals should be closely observed post injection and appropriate antibiotic therapy initiated at the first sign(s) of infection. Very rarely, anaphylactic reactions have occurred after administration of the product. Overdose: At 50 and 100 times the recommended dose of cloprostenol mild side effects may be detected. These include increased uneasiness, mild transient diarrhea, slight frothing, and milk letdown. |
Veterinary Drugs and Treatments | Cloprostenol is approved for use in beef or dairy cattle to induce luteolysis. It is recommended by the manufacturer for unobserved or undetected estrus in cows cycling normally, pyometra or chronic endometritis, expulsion of mummified fetus, luteal cysts, induced abortions after mismating, and to schedule estrus and ovulation for controlled breeding. Cloprostenol has been used in dogs for pregnancy termination and treatment of open pyometra. The use of cloprostenol for pyometra is controversial as some believe dinoprost (PGF2alpha) is more effective and has fewer adverse effects than cloprostenol. |
Solubility in water | Soluble in H2O. |
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