Shanghaitwochem Supply Factory Price Pharmaceutical Powder 99% Purity Pharmaceutical CAS 104987-11-3 Tacrolimus Purity Tacrolimus Powder Tacrolimus

• Customization: Available
• CAS No.: 104987-11-3
• Formula: C44h69no12
• Model NO.: TAPI-428
• EINECS: 1308068-626-2
• Type: Pharmaceutical Intermediates
• Appearance: Powder
• Quality: Industrial
• Colour: White
• Grade Standard: Pharmaceutical Grade
• Shelf Life: 2 Years Proper Storage
• Color: White
• Storage: Cool Dry Place
• Model: Tapi-428
• Application: Functional Ingridents
• CAS: 104987-11-3
• Test: HPLC
• Assay: 99%
• Sample: Avaliable
• MW: 804.02
• Transport Package: Standard Packaging or Customized to Your Needs
• Specification: 1KG 5KG 25KG 50KG
• Trademark: Twochem
• Origin: Zhejiang Province
• HS Code: 2930909099
• Production Capacity: 5000kg/Year

Product Description

 

 

Our Advantages

1.Free Samples.
2.MOQ:500g.
3.More than 3000 kinds of animal drugs.
4.More than 11+ manufacturing experience.
5.Certification:MSDS,HALAL,COA,IFRA,ISO9001, ISO22000,26 Allergens, etc.
6.Lead time:about 8-12 working days.
8.Verified by Made-in-China as Golden Supplier.



 

Product Description

 

 

What is Tacrolimus Powder CAS 104987-11-3? 

 

 

Product Name	Tacrolimus
CAS NO.	104987-11-3
Purity	99%
Density	1.19
Appearance and shape	White powder

Tacrolimus, also known as FK506, is a fermentation product isolated from Streptomyces. It is a macrolide antibiotic and a powerful new immunosuppressant, mainly by inhibiting interleukin-2 The release of (IL-2) completely inhibits the effect of T lymphocytes, which is 100 times stronger than cyclosporine (CsA). In recent years, as a first-line drug for liver and kidney transplantation, it has been marketed in 14 countries including Japan and the United States. Clinical experiments show that it has a good effect in transplantation of heart, lung, intestine, bone marrow, etc. At the same time, FK506 also plays an active role in the treatment of atopic dermatitis (AD), systemic lupus erythematosus (SLE), autoimmune eye disease and other autoimmune diseases.

 

 

 Function of Tacrolimus Powder CAS 104987-11-3

1.Tacrolimus is used to treat atopic dermatitis (more commonly known as eczema). It is a topical medication which is normally prescribed for patients who have not responded successfully to other eczema medication.
2.Tacrolimus is a type of topical calcineurin inhibitor (TCIs) that works by weakening the patient`s immune system, which as a consequence directly reduces the severity of eczema and its symptoms. It should not be used by patients who have any kind of weak immune system.
Applications
1.The mechanism of action of tacrolimus in atopic dermatitis is not known.  the clinical significance of these observations in atopic dermatitis is not known. It has been demonstrated that tacrolimus inhibits T-lymphocyte activation by first binding to an intracellular protein, FKBP-12.
2.A complex of tacrolimus-FKBP-12, calcium, calmodulin, and calcineurin is then formed and the phosphatase activity of calcineurin is inhibited. This prevents the dephosphorylation and translocation of nuclear factor of activated T-cells (NF-AT), a nuclear component thought to initiate gene transcription for the formation of lymphokines.
3.Tacrolimus also inhibits the transcription for genes which encode IL-3, IL-4, IL-5, GM-CSF, and TNF-, all of which are involved in the early stages of T-cell activation. Additionally, tacrolimus has been shown to inhibit the release of pre-formed mediators from skin mast cells and basophils, and to downregulate the expression of FceRI on Langerhans cells.

 

 

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Company Profile

 

 

 

 

 

 

 

 

 

 

 

ShangHai Twochem is one of professional groups specialized in research, development, custom manufacturing and trading of pharmaceutical API, advanced intermediates, food supplements, hookah additive flavors ,Cosmetic raw materials, health and cosmetic raw materials, polypeptides, animal drug and organic reagent  etc. You can select more than 2000 kinds of raw ingredients here. And we are keeping developing new products and continuously marketing them for sale. You will save lots of time , energy, money and have a very pleasant cooperation with us! We have cooperated with local Medicine Inspection Center as our QC center. We have customer manufacture sites managed under GMP guidline in Anhui and Jiangsu Province, China. We have good relationship with many pharmaceutical research Institute and Universities in China. 

 

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Q&A

1.How could l get a sample?
Before we received the first order, please afford the sample cost and express fee. We wilreturn  the sample cost back to you within your first order.

2.Can you make designs for us?
We have a professional design team to help our customers do design work.Both OEM and ODM          orders are accepted.

3.Can we get samples from your factory?
We can provide you samples for free, you just pay express cost.

4.Whether you could make our brand on your products?
Yes. We can print your Logo on both the products and the packages if you can meet our MOQ
How can you provide us high quality products?

5.We have a professional QC team, every product is shipped after strictly examination.
What is your lead time?
Quantity about 10000 pcs is 15-20 days ,small orders are about one week.
Huge orders to be neqotiated.

6.What is your payment?
We accept T/T.L/C.Westem union or to be negotiated.Don't worry about anything, if you have      any problems, please feel free to contact us