Shanghai Twochem Factory Supply Raw Material Alectinib HCl Pharmaceutical Intermediate Alectinib Hydrochloride Powder Alectinib

• Customization: Available
• CAS No.: 1256589-74-8
• Formula: C30h35cln4o2
• Model NO.: TAPI-325
• EINECS: N/M
• Type: Pharmaceutical Intermediates
• Appearance: Powder
• Quality: 99+
• Colour: White
• Grade Standard: Pharmaceutical Grade
• Shelf Life: 2 Years Proper Storage
• Color: White Crystalline Powder
• Storage: Cool Dry Place
• Model: Tapi-325
• Application: API Raw Materials
• CAS: 1256589-74-8
• Test: HPLC
• Assay: 99%
• Sample: Avaliable
• MW: 519.09
• Transport Package: Standard Packaging or Customized to Your Needs
• Specification: 1KG 5KG 25KG 50KG
• Trademark: Twochem
• Origin: Zhejiang Province
• HS Code: 293299909
• Production Capacity: 5000kg/Year

Product Description

 

Our Advantages

1.Free Samples.
2.MOQ:10kg.
3.More than 2000 kinds of animal drugs.
4.More than 11+ manufacturing experience.
5.Certification:MSDS,HALAL,COA,IFRA,ISO9001, ISO22000,26 Allergens, etc.
6.Lead time:about 8-12 working days.
8.Verified by Made-in-China as Golden Supplier.



 

Product Description

 

What is Alectinib Hydrochloride Powder CAS 1256589-74-8 ?
  

 

 

Product Name	Alectinib
CAS No.	1256580-46-7
MF	C30H34N4O2
MW	482.628
Appearance and shape	White Crystalline Powder

 

Alectinib hydrochloride, developed by Chugai Pharmaceutical/ Hoffman-La Roche under the trade name Alecensa, was approved in Japan in April 2014 for the treatment of anaplastic lymphoma kinase (ALK) fusion-gene positive, unresectable, advanced, or recurrent non-small cell lung cancer (NSCLC).    The compound is a highly selective second-generation ALK inhibitor, and while alectinib currently remains a focus of further development in Europe and the U.S., the compound has been granted orphan drug designation in Japan after showing a 93.5% objective response rate in phase II clinical trials.    In addition to providing rapid treatment response time in a majority of patients, trials showed a 76% 2-year progression-free survival rate.    Since the initial approval of crizotinib-the first ALK inhibitor indicated for treatment of ALKrearranged NSCLC -patients treated with crizotinib have shown remarkable improvement as compared to treatment with other chemotherapeutic methods,21 although drug resistance has shown to be a major side effect of this therapy.    Preliminary preclinical and clinical studies of alectinib have shown significant promise for overcoming drug resistance developed with other ALK inhibitors.
Alectinib hydrochloride is a highly selective and potent anaplastic lymphoma kinase (ALK) inhibitor capable of blocking the resistant gatekeeper mutant, which results in reduced cell growth.    Also is an intermediate of Alectinib (C183360), a highly selective and potent anaplastic lymphoma kinase (ALK) inhibitor capable of blocking the resistant gatekeeper mutant, which results in reduced cell growth.


 

Function of Alectinib Hydrochloride Powder CAS 1256589-74-8

Alectinib is an orally available inhibitor of the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) with antineoplastic activity.    Upon administration, alectinib binds to and inhibits ALK kinase, ALK fusion proteins as well as the gatekeeper mutation ALKL1196M known as one of the mechanisms of acquired resistance to small-molecule kinase inhibitors.    The inhibition leads to disruption of ALK-mediated signaling and eventually inhibits tumor cell growth in ALK-overexpressing tumor cells.

 

Application

 

 

 

 

 

 

 

Company Profile

 

 

 

ShangHai Twochem is one of professional groups specialized in research, development, custom manufacturing and trading of pharmaceutical API, advanced intermediates, food supplements, hookah additive flavors ,Cosmetic raw materials, health and cosmetic raw materials, polypeptides, animal drug and organic reagent  etc. You can select more than 2000 kinds of raw ingredients here. And we are keeping developing new products and continuously marketing them for sale. You will save lots of time , energy, money and have a very pleasant cooperation with us! We have cooperated with local Medicine Inspection Center as our QC center. We have customer manufacture sites managed under GMP guidline in Anhui and Jiangsu Province, China. We have good relationship with many pharmaceutical research Institute and Universities in China. 


 

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Q&A
1.How could l get a sample?
Before we received the first order, please afford the sample cost and express fee. We wilreturn  the sample cost back to you within your first order.

2.Can you make designs for us?
We have a professional design team to help our customers do design work.Both OEM and ODM          orders are accepted.

3.Can we get samples from your factory?
We can provide you samples for free, you just pay express cost.

4.Whether you could make our brand on your products?
Yes. We can print your Logo on both the products and the packages if you can meet our MOQ
How can you provide us high quality products?

5.We have a professional QC team, every product is shipped after strictly examination.
What is your lead time?
Quantity about 10000 pcs is 15-20 days ,small orders are about one week.
Huge orders to be neqotiated.

6.What is your payment?
We accept T/T.L/C.Westem union or to be negotiated.Don't worry about anything, if you have      any problems, please feel free to contact us