Twochem Lab Supply Raw Materials Pharmaceutical Intermediates Alpelisib Pharmaceutical Powder CAS 1217486-61-7 API with 99% Pruity

• Customization: Available
• Formula: C19h22f3n5o2s
• Type: Pharmaceutical Intermediates
• Model NO.: TAPI-40
• Appearance: Powder
• Quality: Pharmaceutical Grade
• Colour: White
• Powder: Yes
• Customized: Customized
• State: Solid
• Purity: >99%
• Certification: GMP, Hse, ISO 9001, USP, Bp
• Suitable for: Poultry, Pets
• Grade Standard: Pharmaceutical Grade
• Shelf Life: 2 Years Proper Storage
• Color: White Powder
• Storage: Cool Dry Place
• Model: Tapi-40
• Application: API Raw Materials
• CAS: 1217486-61-7
• Test: HPLC
• Assay: 99%
• Sample: Avaliable
• MW: 441.47g/Mol
• Transport Package: Standard Packaging or Customized to Your Needs
• Specification: 1KG 5KG 25KG 50KG
• Trademark: Twochem
• Origin: Zhejiang Province
• HS Code: 293299909
• Production Capacity: 5000kg/Year

Product Description

 

Our Advantages

1.Free Samples.
2.MOQ:10kg.
3.More than 2000 kinds of animal drugs.
4.More than 11+ manufacturing experience.
5.Certification:MSDS,HALAL,COA,IFRA,ISO9001, ISO22000,26 Allergens, etc.
6.Lead time:about 8-12 working days.
8.Verified by Made-in-China as Golden Supplier.



 

Product Description

 

What is Alpelisib/BYL719 ?
  

Name	Alpelisib,CAS 1217486-61-7
Other names	1217486-61-7 BYL-719 BYL719 Piqray NVP-BYL719 Alpelisib (BYL719) UNII-08W5N2C97Q (S)-N1-(4-Methyl-5-(2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl)thiazol-2-yl)pyrrolidine-1,2-dicarboxamide BYL 719 CHEMBL2396661 08W5N2C97Q (2S)-N1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-1,2-pyrrolidinedicarboxamide (2S)-1-N-[4-methyl-5-[2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl]-1,3-thiazol-2-yl]pyrrolidine-1,2-dicarboxamide 1,2-PYRROLIDINEDICARBOXAMIDE, N1-[4-METHYL-5-[2-(2,2,2-TRIFLUORO-1,1-DIMETHYLETHYL)-4-PYRIDINYL]-2-THIAZOLYL]-, (2S)- C19H22F3N5O2S (2s)-N~1~-{4-Methyl-5-[2-(1,1,1-Trifluoro-2-Methylpropan-2-Yl)pyridin-4-Yl]-1,3-Thiazol-2-Yl}pyrrolidine-1,2-Dicarboxamide (S)-N1-(4-methyl-5-(2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl)thiazol-2-yl)pyrrolidine-1,2-dicarboxamide.
Key words	STUWGJZDJHPWGZ-LBPRGKRZSA-N;                                                     API;                                                                                                     Alpelisib uses
CAS number	1217486-61-7
Molecular Formula	C19H22F3N5O2S
Molecular Weight	441.47g/mol
Chemical and Physical Properties
Appearance	White powder
Melting point	N/A
Solubility	Soluble in DMSO
Quality standard	98%
Application
Drug Indication/Application/Use	Anti-tumor
Formulations/Preparations	Tablets
Handling and Storage
Safety and Hazards	The shanghai Research Institute of Chemical industry testing center identification conclusion :1 None hazard identification, 2 The substance is not subject to IATA DGR, 3 Non packing requirements.
Handling and Storage	Under inert gas (nitrogen or Argen) at 2-8°C
Sample package	Double plastic bags inside, aluminum foil bag outside
Commercial package	Double plastic bags inside,5kg, 10kg, 25kg fiber drum outside.
UN Code	Not classified
HS Code	000000000
Shipping group	Shipment at ambient temperature for no controlled and  no dangerous goods
Sales restriction	No
Origin	China
Technnical support
Alpelisib,STD Data sheet Alpelisib,MSDS Alpelisib,COA Alpelisib,Transport Certificate	Yes Yes Yes Yes
Related APIs	(2S,3S)-1-N-[5-(2-tert-butyl-1,3-thiazol-4-yl)-4-methyl-1,3-thiazol-2-yl]-3-methylpyrrolidine- 1,2-dicarboxamide; (S)-N1-(2-(tert-butyl)-4'-methyl-[4,5'-bithiazol]-2'-yl)pyrrolidine-1,2-dicarboxamide; (2S)-2-methyl-1-N-[4-methyl-5-[2-(1-methylcyclopropyl)pyridin-4-yl]-1,3-thiazol-2-yl]pyrrolidine-1,2- dicarboxamide; (2S)-1-N-[5-(2-cyclopropylpyridin-4-yl)-4-methyl-1,3-thiazol-2-yl]-2-methylpyrrolidine-1,2-dicarboxamide; (2S)-1-N-[5-(2-cyclobutylpyridin-4-yl)-4-methyl-1,3-thiazol-2-yl]-2-methylpyrrolidine-1,2-dicarboxamide; (2S)-1-N-[5-[2-(2-fluorophenyl)pyridin-4-yl]-4-methyl-1,3-thiazol-2-yl]-2-methylpyrrolidine-1,2-dicarboxamide
Supply ability
Monthly capacity	/
GMP	No

 

 

Function of Apalutamide

Alpelisib is used for advanced solid tumours. Alpelisib shows statistically significant dose-dependent anti-tumor efficacy in PIK3CA mutant xenograft models in rodents. BYL719 has a low clearance, a half-life of 8.5 h and its exposure increases dose proportionally between 30mg/d and 450mg/d, displaying a low inter-individual variability in Cmax and AUC in human. BYL719(270mg/d) shows first signs of clinical efficacy include 1 confirmed partial response in a patient with ER+ breast cancer, and significant PET responses (PMR) and/or tumor shrinkage are achieved in 8 out of 17 evaluated patients.

 

 

Application

 

 

 

 

 

Company Profile

 

 

ShangHai Twochem is one of professional groups specialized in research, development, custom manufacturing and trading of pharmaceutical API, advanced intermediates, food supplements, hookah additive flavors ,Cosmetic raw materials, health and cosmetic raw materials, polypeptides, animal drug and organic reagent  etc. You can select more than 2000 kinds of raw ingredients here. And we are keeping developing new products and continuously marketing them for sale. You will save lots of time , energy, money and have a very pleasant cooperation with us! We have cooperated with local Medicine Inspection Center as our QC center. We have customer manufacture sites managed under GMP guidline in Anhui and Jiangsu Province, China. We have good relationship with many pharmaceutical research Institute and Universities in China. 


 

Factory display

 

 

 

 

 

Q&A
1.How could l get a sample?
Before we received the first order, please afford the sample cost and express fee. We wilreturn  the sample cost back to you within your first order.

2.Can you make designs for us?
We have a professional design team to help our customers do design work.Both OEM and ODM          orders are accepted.

3.Can we get samples from your factory?
We can provide you samples for free, you just pay express cost.

4.Whether you could make our brand on your products?
Yes. We can print your Logo on both the products and the packages if you can meet our MOQ
How can you provide us high quality products?

5.We have a professional QC team, every product is shipped after strictly examination.
What is your lead time?
Quantity about 10000 pcs is 15-20 days ,small orders are about one week.
Huge orders to be neqotiated.

6.What is your payment?
We accept T/T.L/C.Westem union or to be negotiated.Don't worry about anything, if you have      any problems, please feel free to contact us