Twochem High Quality Pharmaceutical Raw Material Pure Lorlatinib Intermediate CAS 1454846-35-5 with Best Price

• Customization: Available
• Formula: C21h19fn6o2
• EINECS: 600-848-7
• Model NO.: TAPI-46
• Type: Pharmaceutical Intermediates
• Appearance: Powder
• Quality: Pharmaceutical Grade
• Colour: White
• Powder: Yes
• Customized: Customized
• State: Solid
• Purity: >99%
• Certification: GMP, Hse, ISO 9001, USP, Bp
• Suitable for: Poultry, Pets
• Grade Standard: Pharmaceutical Grade
• Shelf Life: 2 Years Proper Storage
• Color: White Powder
• Storage: Cool Dry Place
• Model: Tapi-46
• Application: API Raw Materials
• CAS: 1454846-35-5
• Test: HPLC
• Assay: 99%
• Sample: Avaliable
• Transport Package: Standard Packaging or Customized to Your Needs
• Specification: 1KG 5KG 25KG 50KG
• Trademark: Twochem
• Origin: Zhejiang Province
• HS Code: 293299909
• Production Capacity: 5000kg/Year

Product Description

 

Our Advantages

1.Free Samples.
2.MOQ:10kg.
3.More than 2000 kinds of animal drugs.
4.More than 11+ manufacturing experience.
5.Certification:MSDS,HALAL,COA,IFRA,ISO9001, ISO22000,26 Allergens, etc.
6.Lead time:about 8-12 working days.
8.Verified by Made-in-China as Golden Supplier.



 

Product Description

 

What is Lorlatinib??
  

 

Lorlatinib (PF-06463922) is a new drug under development for the sub-group of advanced non-small cell lung cancerwho are ALK or ROS1 positive and have already undergone gene treatment with drugs thatspecifically targetthis type of cancer.Lorlatinib is currently being evaluated in phase II clinical trials as an oral dose at 100 mg daily. If marketed it will becomean additional targeted treatment for this sub-group of ALKor ROS1 positive patients.
Lorlatinib acts by inhibiting the ALK and ROS1 receptor tyrosine kinases, with potent activity against a broad spectrum of ALK resistant mutations. By inhibiting ALK phosphorylation and ROS1 activity, lorlatinib inhibits the downstream signalling, thereby inducing the apoptosis process, which results in the inhibition of tumour cells proliferation.
Due to tumor complexity and development of resistance to treatment, disease progression is a challenge in patients with ALK-positive metastatic non-small cell lung cancer (NSCLC). A common site for progression in metastatic NSCLC is the brain.
Lorlatinib was specifically designed to inhibit tumor mutations that drive resistance to other ALK inhibitors and to penetrate the blood brain barrier.
Due to tumor complexity and development of resistance to treatment, disease progression is a challenge in patients with ALK-positive metastatic non-small cell lung cancer (NSCLC). A common site for progression in metastatic NSCLC is the brain.
Lorlatinib was specifically designed to inhibit tumor mutations that drive resistance to other ALK inhibitors and to penetrate the blood brain barrier.
 

Product Name	Lorlatinib
CAS No.	1454846-35-5
Purity	99%
MF	C21H19FN6O2
Appearance and shape	White  powder

Function of Lorlatinib
  

Lorlatinib should be regarded as a third-generation ALK inhibitor. It can inhibit 9 mutations that are resistant to crizotinib. It has strong blood-brain barrier penetration ability and strong brain entry effect. It is especially suitable for resistance to other ALKs. of patients with advanced NSCLC. Lorlatinib carries EGFR-sensitive mutations in advanced non-small cell lung cancer, which can be treated with Chemicalbook by many EGFR inhibitors, such as the first-generation drugs Iressa, Tarceva, and Chimera, and the second-generation drugs afatinib , Dacomitinib, the third-generation drug osimertinib (AZD9291)-the effective rate of these targeted drugs is as high as 70% or even higher, and the side effects are not too small. They are the first choice for the treatment of such patients.

 

 

Application

 

 

 

 

 

Company Profile

 

 

ShangHai Twochem is one of professional groups specialized in research, development, custom manufacturing and trading of pharmaceutical API, advanced intermediates, food supplements, hookah additive flavors ,Cosmetic raw materials, health and cosmetic raw materials, polypeptides, animal drug and organic reagent  etc. You can select more than 2000 kinds of raw ingredients here. And we are keeping developing new products and continuously marketing them for sale. You will save lots of time , energy, money and have a very pleasant cooperation with us! We have cooperated with local Medicine Inspection Center as our QC center. We have customer manufacture sites managed under GMP guidline in Anhui and Jiangsu Province, China. We have good relationship with many pharmaceutical research Institute and Universities in China. 


 

Factory display

 

 

 

 

 

Q&A
1.How could l get a sample?
Before we received the first order, please afford the sample cost and express fee. We wilreturn  the sample cost back to you within your first order.

2.Can you make designs for us?
We have a professional design team to help our customers do design work.Both OEM and ODM          orders are accepted.

3.Can we get samples from your factory?
We can provide you samples for free, you just pay express cost.

4.Whether you could make our brand on your products?
Yes. We can print your Logo on both the products and the packages if you can meet our MOQ
How can you provide us high quality products?

5.We have a professional QC team, every product is shipped after strictly examination.
What is your lead time?
Quantity about 10000 pcs is 15-20 days ,small orders are about one week.
Huge orders to be neqotiated.

6.What is your payment?
We accept T/T.L/C.Westem union or to be negotiated.Don't worry about anything, if you have      any problems, please feel free to contact us