Twochem China Supply Raw Materials Pharmaceutical Intermediates Crizotinib Powder CAS 877399-52-5 API with 99% Pruity

• Customization: Available
• EINECS: C22h17cl2f6n3o3
• Type: Pharmaceutical Intermediates
• Model NO.: TAPI-28
• Appearance: Powder
• Quality: Pharmaceutical Grade
• Colour: White
• Powder: Yes
• Customized: Customized
• State: Solid
• Purity: >99%
• Certification: GMP, Hse, ISO 9001, USP, Bp
• Suitable for: Poultry, Pets
• Grade Standard: Pharmaceutical Grade
• Shelf Life: 2 Years Proper Storage
• Color: Brick-Red Powder
• Storage: Cool Dry Place
• Model: Tapi-28
• Application: API Raw Materials
• CAS: 877399-52-5
• Test: HPLC
• Assay: 99%
• Sample: Avaliable
• Molecular Weight: 556.285104513168t
• Transport Package: Standard Packaging or Customized to Your Needs
• Specification: 1KG 5KG 25KG 50KG
• Trademark: Twochem
• Origin: Zhejiang Province
• HS Code: 293299909
• Production Capacity: 5000kg/Year

Product Description

 

Our Advantages

1.Free Samples.
2.MOQ:10kg.
3.More than 2000 kinds of animal drugs.
4.More than 11+ manufacturing experience.
5.Certification:MSDS,HALAL,COA,IFRA,ISO9001, ISO22000,26 Allergens, etc.
6.Lead time:about 8-12 working days.
8.Verified by Made-in-China as Golden Supplier.



 

Product Description

 

What is Crizotinib?
 

Crizotinib has an aminopyridine structure, and functions as a protein kinase inhibitor by competitive binding within the ATP-binding pocket of target kinases. About 4% of patients with non-small cell lung carcinoma have a chromosomal rearrangement that generates a fusion genebetween EML4 ('echinoderm microtubule-associated protein-like 4') andALK ('anaplastic lymphoma kinase'), which results in constitutivekinase activity that contributes to carcinogenesis and seems to drive the malignant phenotype. The kinase activity of the fusion protein is inhibited by crizotinib. Patients with this gene fusion are typically younger non-smokers who do not have mutations in either theepidermal growth facter receptor gene (EGFR) or in the K-Ras gene.The number of new cases of ALK-fusion NSLC is about 9,000 per year in the U.S. and about 45,000 worldwide.

 

Function of Lenvatinib mesylate
 

 

Product Name	Crizotinib
CAS No.	877399-52-5
MF	C21H22Cl2FN5O
MW	450.34
Appearance and shape	White or off-white crystalline powder

Crizotinib (XalkoriR), chemically known as 3-[(R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]pyridin-2-amine,is a white to light yellow powder. Crizotinib is an anti-cancer drug, It is primarily useful for the treatment of patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) who are positive for mesenchymal lymphoma kinase (ALK) as determined by an SFDA-approved assay.

1.Treating certain types of lung cancer. It may also be used for other conditions as determined by your doctor.
2.Crizotinib is a tyrosine kinase inhibitor. It works by preventing the growth of cancer cells.
3.Crizotinib inhibits the c-Met receptor (HGFR) tyrosine kinase, which is involved in the oncogenesis of a number of other histological forms of malignant neoplasms.
4.Crizotinib is currently thought to exert its effects through modulation of the growth, migration, and invasion of malignant cells.Other studies suggest that crizotinib might also act via inhibition of angiogenesis in malignant tumors.

 

Application

 

 

 

 

 

Company Profile

 

 

ShangHai Twochem is one of professional groups specialized in research, development, custom manufacturing and trading of pharmaceutical API, advanced intermediates, food supplements, hookah additive flavors ,Cosmetic raw materials, health and cosmetic raw materials, polypeptides, animal drug and organic reagent  etc. You can select more than 2000 kinds of raw ingredients here. And we are keeping developing new products and continuously marketing them for sale. You will save lots of time , energy, money and have a very pleasant cooperation with us! We have cooperated with local Medicine Inspection Center as our QC center. We have customer manufacture sites managed under GMP guidline in Anhui and Jiangsu Province, China. We have good relationship with many pharmaceutical research Institute and Universities in China. 


 

Factory display

 

 

 

 

 

Q&A
1.How could l get a sample?
Before we received the first order, please afford the sample cost and express fee. We wilreturn  the sample cost back to you within your first order.

2.Can you make designs for us?
We have a professional design team to help our customers do design work.Both OEM and ODM          orders are accepted.

3.Can we get samples from your factory?
We can provide you samples for free, you just pay express cost.

4.Whether you could make our brand on your products?
Yes. We can print your Logo on both the products and the packages if you can meet our MOQ
How can you provide us high quality products?

5.We have a professional QC team, every product is shipped after strictly examination.
What is your lead time?
Quantity about 10000 pcs is 15-20 days ,small orders are about one week.
Huge orders to be neqotiated.

6.What is your payment?
We accept T/T.L/C.Westem union or to be negotiated.Don't worry about anything, if you have      any problems, please feel free to contact us