| Customization: | Available |
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| CAS No.: | 18883-66-4 |
| Formula: | C8h15n3o7 |
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| Product Name | Streptozotocin |
| CAS No. | 18883-66-4 |
| MF | C8H15N3O7 |
| MW | 265.222 |
| Appearance and shape | White powder |
Streptozotocin is an organic compound with a molecular formula of C8H15N3O7. For small flakes or prism crystals. It is hygroscopic. Soluble in water, lower alcohols and ketones. In an aqueous solution, it changes rotation quickly, and the equilibrium value of specific rotation is [α]D25 +39°. Maximum absorption wavelength (in ethanol): 228 nm (ε 6363). The LD50 (female mouse, abdominal cavity) 360 mg/kg. poisonous. There is a possibility of causing cancer.
Streptozotocin belongs to glucosamine-nitrosourea, which is a DNA alkylation reagent that can enter cells by GLUT2 glucose transport protein (GLUT2 glucose transport protein) alone. Toxic to insulin-induced β-cells. Streptozotocin has a toxic effect on GLUT2-positive neuroendocrine tumor cells.
Function of Streptozotocin Powder CAS 18883-66-4
Streptozotocin is a natural compound produced by Streptococcus and is particularly toxic to insulin-producing islet B cells in the pancreas of mammals. It is a nitrosourea antibiotic.
STZ can form isocyanates in the body. Thereby, it binds to the nucleic acid protein, inhibits the activity of the DNA polymerase, and makes the damaged DNA difficult to repair.
1. Treatment of islet cell tumors (β-cell or non-β-cell carcinoma).
2. It has a certain effect on carcinoid tumors, Hodgkin's disease, colon cancer and liver cancer.
3. Establish animal models of type 1 diabetes in medical research.
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Quantity about 10000 pcs is 15-20 days ,small orders are about one week.
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